Addressing the Obesity-Diabetes Continuum in Cambodia: A Critical Review of Health Policy, Regulation, and Care Delivery System Readiness

Authors

  • Yem Sokha University of Puthisastra
  • Kem Sokunthea University of Puthisastra
  • Tun Sreypeov University of Puthisastra

DOI:

https://doi.org/10.58418/ijni.v5i1.177

Keywords:

Health Policy, Regulatory Frameworks, Care Delivery Readiness, Obesity-Diabetes Continuum, Primary Health Care, Cambodia

Abstract

Cambodia is undergoing a rapid epidemiological transition marked by an escalating continuum of obesity and type 2 diabetes mellitus (T2DM). This study evaluates Cambodia’s health policy responsiveness, regulatory frameworks, and care delivery system readiness to address this shifting chronic disease burden. Synthesizing national data from the Cambodia Demographic and Health Survey 2021–22 and the STEPS Survey 2023 alongside national strategic frameworks, this review provides a critical macro-level policy-linked analysis, filling a vital literature gap by bridging clinical epidemiology with health systems governance. Findings confirm a severe metabolic burden, with 31.7% of adult women overweight/obese, 15.2% experiencing abdominal adiposity, and T2DM prevalence reaching 6.4%. Crucially, 50% of T2DM cases remain undiagnosed, a systemic failure rooted in primary care unreadiness, diagnostic stockouts of HbA1c and lipid panels, and historical prioritization of acute infectious management. Socioeconomic disparities compound this risk, as individuals with no formal education exhibit the highest T2DM prevalence (11.2%). On the regulatory front, current fiscal policies like sugar-sweetened beverage taxation require aggressive strengthening, while financial frameworks like the Health Equity Fund lack preventative screening mandates. This review contributes a novel, multi-level evaluation framework that transitions Cambodia’s public health discourse from passive clinical reporting to active, systemic healthcare reorientation. Ultimately, mitigating this metabolic crisis demands restructuring primary care into chronic care models, expanding financial protection for preventative services, and enforcing multi-sectoral dietary regulations.

References

Alvarado, M., Adams, J., Penney, T., Murphy, M. M., Abdool Karim, S., Egan, N., Rogers, N. T., Carters-White, L., & White, M. (2023). A systematic scoping review evaluating sugar-sweetened beverage taxation from a systems perspective. Nature Food, 4(11), 986–995. https://doi.org/10.1038/s43016-023-00856-0

Andreyeva, T., Marple, K., Marinello, S., Moore, T. E., & Powell, L. M. (2022). Outcomes Following Taxation of Sugar-Sweetened Beverages. JAMA Network Open, 5(6), e2215276. https://doi.org/10.1001/jamanetworkopen.2022.15276

Annear, P. L., Tayu Lee, J., Khim, K., Ir, P., Moscoe, E., Jordanwood, T., Bossert, T., Nachtnebel, M., & Lo, V. (2019). Protecting the poor? Impact of the national health equity fund on utilization of government health services in Cambodia, 2006-2013. BMJ Global Health, 4(6), e001679. https://doi.org/10.1136/bmjgh-2019-001679

Anyasodor, A. E., Nwose, E. U., Bwititi, P. T., & Richards, R. S. (2022). Cost-effectiveness of community diabetes screening: Application of Akaike information criterion in rural communities of Nigeria. Frontiers in Public Health, 10, 932631. https://doi.org/10.3389/fpubh.2022.932631

Asahara, S., Inoue, H., & Kido, Y. (2022). Regulation of Pancreatic β-Cell Mass by Gene-Environment Interaction. Diabetes & Metabolism Journal, 46(1), 38–48. https://doi.org/10.4093/dmj.2021.0045

Bahari, N. I., Ahmad, N., Mahmud, M. H., Baharom, M., Amir, S. M., Peng, C. S., Hassan, M. R., & Nawi, A. M. (2023). Issues and Challenges in the Primary Prevention of Type 2 Diabetes Mellitus: A Systematic Review. Journal of Prevention, 44(1), 105–125. https://doi.org/10.1007/s10935-022-00707-x

Brown, A., Trimble, M., Sokal-Gutierrez, K., Fernald, L., Madsen, K., & Turton, B. (2024). Sugar-Sweetened Beverages, Foods of Low Nutritional Value, and Child Undernutrition in Cambodia. International Journal of Environmental Research and Public Health, 21(2), 169. https://doi.org/10.3390/ijerph21020169

Buitinga, M., Veeraiah, P., Haans, F., & Schrauwen‐Hinderling, V. B. (2023). Ectopic lipid deposition in muscle and liver, quantified by proton magnetic resonance spectroscopy. Obesity, 31(10), 2447–2459. https://doi.org/10.1002/oby.23865

Butler, A. E., English, E., Kilpatrick, E. S., Östlundh, L., Chemaitelly, H. S., Abu-Raddad, L. J., Alberti, K. G. M. M., Atkin, S. L., & John, W. G. (2021). Diagnosing type 2 diabetes using Hemoglobin A1c: a systematic review and meta-analysis of the diagnostic cutpoint based on microvascular complications. Acta Diabetologica, 58(3), 279–300. https://doi.org/10.1007/s00592-020-01606-5

Cao, Y., Widyahening, I., Sun, X., & Li, S. (2025). Pathophysiology of type 2 diabetes: A focus on the metabolic differences among southeast Asian, Chinese and Indian populations and how this impacts treatment. Diabetes, Obesity and Metabolism, 27(S10), 3–14. https://doi.org/10.1111/dom.70060

Carmona, C., Baxter, S., & Carroll, C. (2021). Systematic review of the methodological literature for integrating qualitative evidence syntheses into health guideline development. Research Synthesis Methods, 12(4), 491–505. https://doi.org/10.1002/jrsm.1483

Chait, A., & den Hartigh, L. J. (2020). Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease. Frontiers in Cardiovascular Medicine, 7. https://doi.org/10.3389/fcvm.2020.00022

Chan, W.-K., Chuah, K.-H., Rajaram, R. B., Lim, L.-L., Ratnasingam, J., & Vethakkan, S. R. (2023). Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review. Journal of Obesity & Metabolic Syndrome, 32(3), 197–213. https://doi.org/10.7570/jomes23052

Chavakis, T., Alexaki, V. I., & Ferrante, A. W. (2023). Macrophage function in adipose tissue homeostasis and metabolic inflammation. Nature Immunology, 24(5), 757–766. https://doi.org/10.1038/s41590-023-01479-0

Chham, S., Van Olmen, J., Van Damme, W., Chhim, S., Buffel, V., Wouters, E., & Ir, P. (2023). Scaling-up integrated type-2 diabetes and hypertension care in Cambodia: what are the barriers to health system performance? Frontiers in Public Health, 11, 1136520. https://doi.org/10.3389/fpubh.2023.1136520

Chhim, S., Kowal, P., Ng, N., Naidoo, N., Snodgrass, J., DeLouize, A., Ku, G. M., Sopheab, H., & Klipstein-Grobusch, K. (2026). Prevalence, diagnostic coverage, medication treatment, and glycaemic control of diabetes and associated factors in Cambodia: A cross-sectional study based on the 2023 World Health Survey Plus. Public Health, 254, 106226. https://doi.org/10.1016/j.puhe.2026.106226

Chhim, S., Ku, G. V, Kowal, P., Te, V., Sorithisey, M., Ngor, C., Walton, P., Maung, K. T., Ng, N., Naidoo, N., Por, I., Klipstein-Grobusch, K., Chhea, C., & Sopheab, H. (2026). Prevalence and factors associated with pre-diabetes and undiagnosed diabetes in Cambodia: cross-sectional study based on the World Health Survey Plus 2023. BMJ Open, 16(1), e102715. https://doi.org/10.1136/bmjopen-2025-102715

Comey, C., Anindya, K., Santosa, A., Kowal, P., Chhim, S., Sopheab, H., & Ng, N. (2025). Identifying Subgroups At-Risk for Noncommunicable Diseases in Cambodia: A Latent Class Analysis of Behavioral and Metabolic Risk Factor Patterns. Journal of Epidemiology and Global Health, 15(1), 119. https://doi.org/10.1007/s44197-025-00464-0

Dufour, E., Bolduc, J., Leclerc-Loiselle, J., Charette, M., Dufour, I., Roy, D., Poirier, A.-A., & Duhoux, A. (2023). Examining nursing processes in primary care settings using the Chronic Care Model: an umbrella review. BMC Primary Care, 24(1), 176. https://doi.org/10.1186/s12875-023-02089-3

Fadlallah, R., El-Jardali, F., Nomier, M., Hemadi, N., Arif, K., Langlois, E. V., & Akl, E. A. (2019). Using narratives to impact health policy-making: a systematic review. Health Research Policy and Systems, 17(1), 26. https://doi.org/10.1186/s12961-019-0423-4

Feldhaus, I., Nagpal, S., & Verguet, S. (2021). Alleviating the burden of diabetes with Health Equity Funds: Economic evaluation of the health and financial risk protection benefits in Cambodia. PLOS ONE, 16(11), e0259628. https://doi.org/10.1371/journal.pone.0259628

Forberger, S., Reisch, L., Meshkovska, B., Lobczowska, K., Scheller, D. A., Wendt, J., Christianson, L., Frense, J., Steinacker, J. M., Luszczynska, A., & Zeeb, H. (2022). Sugar-sweetened beverage tax implementation processes: results of a scoping review. Health Research Policy and Systems, 20(1), 33. https://doi.org/10.1186/s12961-022-00832-3

Ganasegeran, K., Abdul Manaf, M. R., Waller, L. A., Safian, N., Mohd Rizal, M. F., Chiew, W. L., Mustapha, F., & Abdul Maulud, K. N. (2025). Impact of Commercial Food Environments on Local Type 2 Diabetes Burden: Cross-Sectional and Ecological Multimodeling Study. JMIR Public Health and Surveillance, 11, e70045. https://doi.org/10.2196/70045

Ganderats-Fuentes, M., & Morgan, S. (2023). Front-of-Package Nutrition Labeling and Its Impact on Food Industry Practices: A Systematic Review of the Evidence. Nutrients, 15(11), 2630. https://doi.org/10.3390/nu15112630

Grabner, G. F., Xie, H., Schweiger, M., & Zechner, R. (2021). Lipolysis: cellular mechanisms for lipid mobilization from fat stores. Nature Metabolism, 3(11), 1445–1465. https://doi.org/10.1038/s42255-021-00493-6

Grant, B., Sandelson, M., Agyemang-Prempeh, B., & Zalin, A. (2021). Managing obesity in people with type 2 diabetes. Clinical Medicine, 21(4), e327–e331. https://doi.org/10.7861/clinmed.2021-0370

Hammaker, J., Anda, D., Kozakiewicz, T., Bachina, V., Berretta, M., Shisler, S., & Lane, C. (2022). Systematic review on fiscal policy interventions in nutrition. Frontiers in Nutrition, 9, 1404372. https://doi.org/10.3389/fnut.2022.967494

Haruyama, R., Rahman, M. S., Rahman, M. M., Khim, S. A., Moadsiri, A., Chham, S., Chhim, S., Kol, H., & Phy, M. (2025). Educational and economic disparities and risk factors associated with diabetes and impaired fasting glucose in Cambodia: analysis of a national population-based study. Journal of Global Health, 15, 04251. https://doi.org/10.7189/jogh.15.04251

Hattersley, L., & Mandeville, K. L. (2023). Global Coverage and Design of Sugar-Sweetened Beverage Taxes. JAMA Network Open, 6(3), e231412. https://doi.org/10.1001/jamanetworkopen.2023.1412

Hill-Briggs, F., Adler, N. E., Berkowitz, S. A., Chin, M. H., Gary-Webb, T. L., Navas-Acien, A., Thornton, P. L., & Haire-Joshu, D. (2021). Social Determinants of Health and Diabetes: A Scientific Review. Diabetes Care, 44(1), 258–279. https://doi.org/10.2337/dci20-0053

Hinnouho, G., Ferguson, E. L., MacDougall, A., Kroeun, H., Sophonneary, P., Chea, M., & Pries, A. M. (2023). High consumption of unhealthy commercial foods and beverages tracks across the complementary feeding period in rural/peri‐urban Cambodia. Maternal & Child Nutrition, 19(2), e13485. https://doi.org/10.1111/mcn.13485

Huangfu, P., Pearson, F., Abu-Hijleh, F. M., Wahlich, C., Willis, K., Awad, S. F., Abu-Raddad, L. J., & Critchley, J. A. (2024). Impact of price reductions, subsidies, or financial incentives on healthy food purchases and consumption: a systematic review and meta-analysis. The Lancet Planetary Health, 8(3), e197–e212. https://doi.org/10.1016/S2542-5196(24)00004-4

Iliodromiti, S., McLaren, J., Ghouri, N., Miller, M. R., Dahlqvist Leinhard, O., Linge, J., Ballantyne, S., Platt, J., Foster, J., Hanvey, S., Gujral, U. P., Kanaya, A., Sattar, N., Lumsden, M. A., & Gill, J. M. R. (2023). Liver, visceral and subcutaneous fat in men and women of South Asian and white European descent: a systematic review and meta-analysis of new and published data. Diabetologia, 66(1), 44–56. https://doi.org/10.1007/s00125-022-05803-5

Jithitikulchai, T., Feldhaus, I., Bauhoff, S., & Nagpal, S. (2021). Health equity funds as the pathway to universal coverage in Cambodia: care seeking and financial risk protection. Health Policy and Planning, 36(1), 26–34. https://doi.org/10.1093/heapol/czaa151

Kawai, T., Autieri, M. V., & Scalia, R. (2021). Adipose tissue inflammation and metabolic dysfunction in obesity. American Journal of Physiology-Cell Physiology, 320(3), C375–C391. https://doi.org/10.1152/ajpcell.00379.2020

Khanna, S., Gan, G. C. H., Sindone, A. P., Tromp, J., Butler, J., Foo, R., Nerlekar, N., & Bhat, A. (2026). Asia at the Epicenter of the Global Cardiometabolic Shift. JACC: Asia, 6(3), 269–283. https://doi.org/10.1016/j.jacasi.2026.01.001

Khin, P. P., Lee, J. H., & Jun, H.-S. (2023). Pancreatic Beta-cell Dysfunction in Type 2 Diabetes. European Journal of Inflammation, 21. https://doi.org/10.1177/1721727X231154152

Kozawa, J., & Shimomura, I. (2021). Ectopic Fat Accumulation in Pancreas and Heart. Journal of Clinical Medicine, 10(6), 1326. https://doi.org/10.3390/jcm10061326

Lane, M. M., Gamage, E., Du, S., Ashtree, D. N., McGuinness, A. J., Gauci, S., Baker, P., Lawrence, M., Rebholz, C. M., Srour, B., Touvier, M., Jacka, F. N., O’Neil, A., Segasby, T., & Marx, W. (2024). Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses. BMJ, e077310. https://doi.org/10.1136/bmj-2023-077310

Lei, X., Qiu, S., Yang, G., & Wu, Q. (2023). Adiponectin and metabolic cardiovascular diseases: Therapeutic opportunities and challenges. Genes & Diseases, 10(4), 1525–1536. https://doi.org/10.1016/j.gendis.2022.10.018

Lemmer, I. L., Willemsen, N., Hilal, N., & Bartelt, A. (2021). A guide to understanding endoplasmic reticulum stress in metabolic disorders. Molecular Metabolism, 47, 101169. https://doi.org/10.1016/j.molmet.2021.101169

Longhini, J., Canzan, F., Mezzalira, E., Saiani, L., & Ambrosi, E. (2022). Organisational models in primary health care to manage chronic conditions: A scoping review. Health & Social Care in the Community, 30(3), e565–e588. https://doi.org/10.1111/hsc.13611

Lu, S., Li, Y., Qian, Z., Zhao, T., Feng, Z., Weng, X., & Yu, L. (2023). Role of the inflammasome in insulin resistance and type 2 diabetes mellitus. Frontiers in Immunology, 14, 1052756. https://doi.org/10.3389/fimmu.2023.1052756

Ministry of Health Cambodia. (2022). National Strategic Plan for the Prevention and Control of Noncommunicable Diseases 2022–2030. https://extranet.who.int/ncdccs/Data/KHM_B3_S23_2.NSP-NCD 2022-2030 English-FINAL.pdf

Ministry of Health Cambodia, & World Health Organization. (2025). Cambodia STEPS Survey 2023: National Survey on Risk Factors for Noncommunicable Diseases. https://cdn.who.int/media/docs/default-source/ncds/ncd-surveillance/data-reporting/cambodia/cambodia-2023-steps-report-english-final.pdf

Misra, A., Vikram, N. K., Ghosh, A., Ranjan, P., & Gulati, S. (2025). Revised definition of obesity in Asian Indians living in India. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 19(1), 102989. https://doi.org/10.1016/j.dsx.2024.102989

Mohan, V. (2025). Lessons Learned From Epidemiology of Type 2 Diabetes in South Asians: Kelly West Award Lecture 2024. Diabetes Care, 48(2), 153–163. https://doi.org/10.2337/dci24-0046

National Institute of Statistics (NIS), Ministry of Health (MoH), & ICF. (2023). Cambodia Demographic and Health Survey 2021–22. https://dhsprogram.com/pubs/pdf/FR377/FR377.pdf

Nugrahani, A. S. D., Muharram, F. R., Novida, H., Swannjo, J. B., Wibisono, S., & Wungu, C. D. K. (2025). Trends and disability-attributable risk factors of type 2 diabetes mellitus in Southeast Asia (1990–2019): An in-depth 30-year analysis from the Global Burden of Disease study. Nutrition, Metabolism and Cardiovascular Diseases, 35(1), 103750. https://doi.org/10.1016/j.numecd.2024.09.020

Nutbeam, D., & Lloyd, J. E. (2021). Understanding and Responding to Health Literacy as a Social Determinant of Health. Annual Review of Public Health, 42(1), 159–173. https://doi.org/10.1146/annurev-publhealth-090419-102529

Oberhauser, L., & Maechler, P. (2021). Lipid-Induced Adaptations of the Pancreatic Beta-Cell to Glucotoxic Conditions Sustain Insulin Secretion. International Journal of Molecular Sciences, 23(1), 324. https://doi.org/10.3390/ijms23010324

OECD/WHO. (2022). Health at a Glance: Asia/Pacific 2022. OECD Publishing. https://doi.org/10.1787/c7467f62-en

Ortega, M. A., De Leon-Oliva, D., García-Montero, C., Fraile-Martinez, O., Boaru, D. L., de Castro, A. V., Saez, M. A., Lopez-Gonzalez, L., Bujan, J., Alvarez-Mon, M. A., García-Honduvilla, N., Diaz-Pedrero, R., & Alvarez-Mon, M. (2023). Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities. Frontiers in Immunology, 14, 1232629. https://doi.org/10.3389/fimmu.2023.1232629

Phonsuk, P., Vongmongkol, V., Ponguttha, S., Suphanchaimat, R., Rojroongwasinkul, N., & Swinburn, B. A. (2021). Impacts of a sugar sweetened beverage tax on body mass index and obesity in Thailand: A modelling study. PLOS ONE, 16(4), e0250841. https://doi.org/10.1371/journal.pone.0250841

Popkin, B. M., & Ng, S. W. (2022). The nutrition transition to a stage of high obesity and noncommunicable disease prevalence dominated by ultra‐processed foods is not inevitable. Obesity Reviews, 23(1), e13366. https://doi.org/10.1111/obr.13366

Roberto, C. A., Ng, S. W., Ganderats-Fuentes, M., Hammond, D., Barquera, S., Jauregui, A., & Taillie, L. S. (2021). The Influence of Front-of-Package Nutrition Labeling on Consumer Behavior and Product Reformulation. Annual Review of Nutrition, 41(1), 529–550. https://doi.org/10.1146/annurev-nutr-111120-094932

Römer, A., Linn, T., & Petry, S. F. (2021). Lipotoxic Impairment of Mitochondrial Function in β-Cells: A Review. Antioxidants, 10(2), 293. https://doi.org/10.3390/antiox10020293

Ruze, R., Liu, T., Zou, X., Song, J., Chen, Y., Xu, R., Yin, X., & Xu, Q. (2023). Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments. Frontiers in Endocrinology, 14, 1161521. https://doi.org/10.3389/fendo.2023.1161521

Sagastume, D., Siero, I., Mertens, E., Cottam, J., Colizzi, C., & Peñalvo, J. L. (2022). The effectiveness of lifestyle interventions on type 2 diabetes and gestational diabetes incidence and cardiometabolic outcomes: A systematic review and meta-analysis of evidence from low- and middle-income countries. EClinicalMedicine, 53, 101650. https://doi.org/10.1016/j.eclinm.2022.101650

Sayyed Kassem, L., Rajpal, A., Barreiro, M. V., & Ismail‐Beigi, F. (2023). Beta-cell function in type 2 diabetes (T2DM): Can it be preserved or enhanced? Journal of Diabetes, 15(10), 817–837. https://doi.org/10.1111/1753-0407.13446

Scoditti, E., Sabatini, S., Carli, F., & Gastaldelli, A. (2024). Hepatic glucose metabolism in the steatotic liver. Nature Reviews Gastroenterology & Hepatology, 21(5), 319–334. https://doi.org/10.1038/s41575-023-00888-8

Sekar, P., Ventura, E. F., Dhanapal, A. C. T. A., Cheah, E. S. G., Loganathan, A., Quen, P. L., Appukutty, M., Taslim, N. A., Hardinsyah, H., Md Noh, M. F., Lovegrove, J. A., Givens, I., & Vimaleswaran, K. S. (2023). Gene–Diet Interactions on Metabolic Disease-Related Outcomes in Southeast Asian Populations: A Systematic Review. Nutrients, 15(13), 2948. https://doi.org/10.3390/nu15132948

Sharma, M., John, R., Afrin, S., Zhang, X., Wang, T., Tian, M., Sahu, K. S., Mash, R., Praveen, D., & Saif-Ur-Rahman, K. M. (2022). Cost-Effectiveness of Population Screening Programs for Cardiovascular Diseases and Diabetes in Low- and Middle-Income Countries: A Systematic Review. Frontiers in Public Health, 10, 820750. https://doi.org/10.3389/fpubh.2022.820750

Soares Andrade, C. A., Shahin, B., Dede, O., Akpeji, A. O., Ajene, C., Albano Israel, F. E., & Varga, O. (2023). The burden of type 2 diabetes mellitus in states of the European Union and United Kingdom at the national and subnational levels: A systematic review. Obesity Reviews, 24(9). https://doi.org/10.1111/obr.13593

Sorn, V., Suon, M., & Chea, S. (2026). Recent trends of non-communicable diseases in Cambodia: a narrative review of challenges, risk factors, and public health strategies. Frontiers in Public Health, 14, 1799131. https://doi.org/10.3389/fpubh.2026.1799131

Sun, H., Saeedi, P., Karuranga, S., Pinkepank, M., Ogurtsova, K., Duncan, B. B., Stein, C., Basit, A., Chan, J. C. N., Mbanya, J. C., Pavkov, M. E., Ramachandaran, A., Wild, S. H., James, S., Herman, W. H., Zhang, P., Bommer, C., Kuo, S., Boyko, E. J., & Magliano, D. J. (2022). IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice, 183, 109119. https://doi.org/10.1016/j.diabres.2021.109119

Sung, K., & Lee, S. (2025). Social determinants of health and type 2 diabetes in Asia. Journal of Diabetes Investigation, 16(6), 971–983. https://doi.org/10.1111/jdi.70024

Taillie, L. S., Reyes, M., Colchero, M. A., Popkin, B., & Corvalán, C. (2020). An evaluation of Chile’s Law of Food Labeling and Advertising on sugar-sweetened beverage purchases from 2015 to 2017: A before-and-after study. PLOS Medicine, 17(2), e1003015. https://doi.org/10.1371/journal.pmed.1003015

Te, V., Chhim, S., Buffel, V., Van Damme, W., van Olmen, J., Ir, P., & Wouters, E. (2023). Evaluation of Diabetes Care Performance in Cambodia Through the Cascade-of-Care Framework: Cross-Sectional Study. JMIR Public Health and Surveillance, 9, e41902. https://doi.org/10.2196/41902

Te, V., Long, S., Van Damme, W., Ir, P., Wouters, E., & Van Olmen, J. (2024). An in-depth Analysis of the Degree of Implementation of Integrated Care for Diabetes in Primary Health Care in Cambodia. International Journal of Integrated Care, 24, 11. https://doi.org/10.5334/ijic.7602

Te, V., Ma, S., Por, I., Van Damme, W., Wouters, E., & van Olmen, J. (2023). Diabetes care components effectively implemented in the ASEAN health systems: an umbrella review of systematic reviews. BMJ Open, 13(10), e071427. https://doi.org/10.1136/bmjopen-2022-071427

Te, V., Wouters, E., Buffel, V., Van Damme, W., van Olmen, J., & Ir, P. (2022). Generation of Cascades of Care for Diabetes and Hypertension Care Continuum in Cambodia: Protocol for a Population-Based Survey Protocol. JMIR Research Protocols, 11(9), e36747. https://doi.org/10.2196/36747

Teufel, F., Orgutsova, K., Genitsaridi, I., Carrillo-Larco, R. M., Varghese, J. S., Marcus, M. E., Sacre, J. W., Sajjadi, S. F., Chiwanga, F., Manne-Goehler, J., Seiglie, J., Flood, D., Harding, J., Salpea, P., Salim, A., Boyko, E. J., Magliano, D. J., & Ali, M. K. (2026). Global, Regional, and National Estimates of Undiagnosed Diabetes in Adults: Findings From the 2025 IDF Diabetes Atlas. Diabetes Care, 49(3), 490–496. https://doi.org/10.2337/dc25-2583

Um, S., & An, Y. (2024). Factors associated with overweight and obesity among women of reproductive age in Cambodia: Analysis of Cambodia Demographic and Health Survey 2021–22. PLOS Global Public Health, 4(1), e0002537. https://doi.org/10.1371/journal.pgph.0002537

Vilas-Boas, E. A., Almeida, D. C., Roma, L. P., Ortis, F., & Carpinelli, A. R. (2021). Lipotoxicity and β-Cell Failure in Type 2 Diabetes: Oxidative Stress Linked to NADPH Oxidase and ER Stress. Cells, 10(12), 3328. https://doi.org/10.3390/cells10123328

Villegas, V., Shah, A., Manson, J. E., & Tobias, D. K. (2022). Prevention of type 2 diabetes through remotely administered lifestyle programs: A systematic review. Contemporary Clinical Trials, 119, 106817. https://doi.org/10.1016/j.cct.2022.106817

White, U. (2023). Adipose tissue expansion in obesity, health, and disease. Frontiers in Cell and Developmental Biology, 11, 1188844. https://doi.org/10.3389/fcell.2023.1188844

Williams, R., & Periasamy, M. (2020). Genetic and Environmental Factors Contributing to Visceral Adiposity in Asian Populations. Endocrinology and Metabolism, 35(4), 681–695. https://doi.org/10.3803/EnM.2020.772

Wondmkun, Y. T. (2020). Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Volume 13, 3611–3616. https://doi.org/10.2147/DMSO.S275898

Wysham, C., & Shubrook, J. (2020). Beta-cell failure in type 2 diabetes: mechanisms, markers, and clinical implications. Postgraduate Medicine, 132(8), 676–686. https://doi.org/10.1080/00325481.2020.1771047

Yanai, H., Adachi, H., Hakoshima, M., Iida, S., & Katsuyama, H. (2023). Metabolic-Dysfunction-Associated Steatotic Liver Disease—Its Pathophysiology, Association with Atherosclerosis and Cardiovascular Disease, and Treatments. International Journal of Molecular Sciences, 24(20), 15473. https://doi.org/10.3390/ijms242015473

Yao, J., Wu, D., & Qiu, Y. (2022). Adipose tissue macrophage in obesity-associated metabolic diseases. Frontiers in Immunology, 13, 977485. https://doi.org/10.3389/fimmu.2022.977485

Zhu, W., Wang, H., Xu, T., Zhang, S., Shan, R., Wang, X., Xu, Y., & Jiang, Y. (2026). Burden of type 2 diabetes in Asia-Pacific regions, 1990–2021: GBD 2021 analysis with forecast to 2050. Diabetic Medicine, 43(4). https://doi.org/10.1111/dme.70216

Downloads

Published

2026-07-29

How to Cite

Sokha, Y., Sokunthea, K., & Sreypeov, T. (2026). Addressing the Obesity-Diabetes Continuum in Cambodia: A Critical Review of Health Policy, Regulation, and Care Delivery System Readiness. International Journal of Nursing Information, 5(1), 1–17. https://doi.org/10.58418/ijni.v5i1.177

Issue

Section

Articles